I have found at least 4 serious crashes so far, one of which makes it impossible to play as D6.
The first one I found that was pretty serious was the first real shootout in Matthius's apartment. If you killed the guy with a headshoot the game would crash. I never did copy the error message. Oops :/
Second one was also as Azriel. Right after you get the option to freely switch between D6 and Azriel, you can search the trash heap next to where you start. If you pick up the magazine Azriel will have two lines of dialog and after the second the game will crash. Crash dialog:
http://bpaste.net/show/XpexpOqOBOgS5MikaQtK/Third is on the fourth floor of an apartment building. There's a reference to Cowboy Bebop, which is Edward and Ein. Usually if you start to load their sprites the game crashes. I say usually because if you make Azriel nock on the door beside them before their sprite loads, he'll knock, say it's locked, then the game crashes. Crash dialog:
http://bpaste.net/show/v6nfv1Ns3xroLNs13ti2/Fourth is where I am currently at. This is as D6, I went through the exercise/test where you have to shot two targets ten times each to get your meal ticket for the day. After the Director congratulates you, it crashes. Crash dialog:
http://bpaste.net/show/Hk3J2aSnDJrpsT0KONfb/I also have the memory dumps for the last three if needed.